Understanding and applying the basics of analysis and assembly of genetic sequences. Introduction to
\nthe basics of analysis of genetic activity in healthy and diseased cells through biological microarrays.
\nObtaining a full picture of genetic functions, including expression profiles at mRNA and protein levels.
\nAbility to assemble and analyse genetic sequences, as well as annotations of genes and proteins in the
\nbody.<\/p>\n
The course covers the basic sequence alignment algorithms and the basics of biology needed to
\nunderstand the genome. The algorithms to be used are: Smith-Waterman, Needleman-Wunsch, BLAST
\nfamily of algorithms. Methods for addressing and correcting genome sequencing errors. Distinguishing
\ngenome sequencing errors from repetitive genome regions. Basics of biology: mutations, a single
\nnucleotide polymorphism, evolutionary distance between genomes of different species. Simulation of
\ngenomes and evolution. Genome function analysis as an important step towards finding new molecules
\n(drugs) that could target proteins in diseased cells. Gene expression, microarrays, their applications (e.g.
\nin the identification of genes expressed in different cell types or different cell states), steps in
\nexperiments with microarrays, quantitative interpretation of results, normalisation, analysis of differential
\ngene expression, basic statistical analysis of results, their visualisation and numerical interpretation, as
\nwell as classification and clustering of data.<\/p>\n
Studying the literature, primarily scientific journals in the field of bioinformatics and computer genomics.<\/p>\n","protected":false},"excerpt":{"rendered":"
Objectives and Outcomes Understanding and applying the basics of analysis and assembly of genetic sequences. Introduction to the basics of analysis of genetic activity in healthy and diseased cells through biological microarrays. Obtaining a full … Read more<\/a><\/p>\n Read more<\/a>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[199],"tags":[],"class_list":["post-14061","post","type-post","status-publish","format-standard","hentry","category-subjects"],"acf":[],"yoast_head":"\n