The subjectc overs the basic algorithms for sequence align ment and the basics of biology necessary for understanding the genome. Algorithms that will be usedare: Smith-Waterman, Needleman-Wunsch, the BLAST family of algorithms; methods for addressing and correct in gerrors in these quencing of the genome; distinguishing errors in these quencing of the genome from the regions of the genome that are repeated. Basic biology: mutation, a single nucleotide polymorphism, evolutionary distance between the genomes of differents pecies. Simulation of genome and evolution.